Methotrexate in rheumatoid arthritis

Efficacy of low-dose methotrexate in rheumatoid arthritis. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Enhanced in vitro induced production of interleukin 10 by peripheral blood mononuclear cells in rheumatoid arthritis is associated with clinical response to methotrexate treatment. Methotrexate remains the anchor drug for rheumatoid arthritis. Xenobiotics or biological response modifiers. Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells. The in vitro effects of methotrexate on peripheral blood mononuclear cells: Modulation by methyl donors and spermidae.